Dengue Fever Modeling with Virus Load and Antibody Levels
Keywords:
Dengue, Virus Load, Antibody Levels, Epidemiology, Mathematical ModelingAbstract
Dengue fever is an arboviral disease transmitted from human to human by the Aedes aegypti mosquito, which has rapidly become one of the most concerning tropical diseases, affecting millions of people every year. The realistic modeling of Dengue transmission and epidemiology presents several challenges: First, being a vector-borne disease, it is important to model the mosquito population in addition to the host (human) population. Second, there are four serotypes of the virus, complicating the epidemiological dynamics. Finally, so-called antibody-dependent enhancement (ADE) can occur, in which the presence of multivalent antibodies from a previous infection can, in certain situations, enhance a new infection. Therefore, it has become apparent that modeling the within-host antibody dynamics can be an important aspect of dengue modeling. Motivated by these observations and the related works, we introduce a new dengue transmission model, taking the form of a system of structured (transport) equations and ODEs.
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References
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